Comprehensive Two-Dimensional Gas Chromatography

LECO GC×GC combined with Electron Capture or Flame Ionization Detectors offer you the resolving power of a GC×GC system combined with our advanced ChromaTOF® software for an increase in efficiency and productivity for samples that are too complex for a single-channel detector system. Ideal for everyday quality control and production needs, these GC×GC systems provide you with all the tools necessary to achieve exceptional results in a cost-effective package.


  • Enhanced separating power for complex sample analysis

  • Easy-to-use ChromaTOF®-based software provides acquisition processing and reporting funtionality within a single package

  • Classification software feature simplifies component identification

  • Flame Ionization Detector (FID) and Electron Capture Detector (ECD) models available

  • Available Cryogen-free modulator eliminates the need for LN2 dewars

Theory of Operation

In GC analysis, chemical compounds are separated by their interaction with the stationary phase in a GC column. Sometimes, however, the separation is not sufficient to provide identification and/or quantification of all compounds. In many situations involving simple sample analysis, the inability to separate two compounds on a GC column with one stationary phase may be resolved by the use of a different column with a different stationary phase. However, as samples become more complex, the simple substitution of one chromatographic stationary phase for another may result in improvements in separation between some compounds with loss of separation between others. In this situation, the combined separation provided by each of two stationary phases is required. As opposed to limited techniques such as heart-cutting, comprehensive two-dimensional gas chromatography (GC×GC) provides superior chromatographic resolution across the entire sample.

In comprehensive two-dimensional gas chromatography (GC×GC) all of the analyte passes from the first column through the second. Compounds eluting from the first chromatographic column are trapped, and then systematically injected into the second column to obtain the second separation. In order to retain the chromatographic resolution obtained from the first separation, the second orthogonal separation must take place quickly. As such, it is important that compounds be introduced into this column quickly and in a narrow chromatographic band. In the LECO GC×GC system, this is accomplished by cryogenic dual-stage modulation. With cryogenic modulation, compounds eluting from the first chromatographic column are trapped in a narrow zone in the column as it passes through the modulator. When this zone is rapidly heated, the trapped compounds pass into the second chromatographic column as a narrow band, allowing for the highest possible resolution in the second separation.

LECO now offers: In order to properly trap and modulate analytes more volatile than n-octane (C8 n-alkane) the lowest achievable modulation temperatures are required. Reaching these low temperatures requires the use of a cryogen such as Liquid Nitrogen (LN2). LECO’s LN2 modulator delivers the ability to modulate these volatile analytes. However, the use and management of LN2 dewars in a laboratory can be a hindrance to productivity. The Consumable-Free modulator is, therefore, an excellent choice for laboratories hesitant to take on the management of LN2 dewars and who do not require modulation of volatile analytes.


Available Models

Available Options

  • Liquid Nitrogen, automated fill
  • Optional inlets available (including S/SL, PTV, and MMI)
  • Optional detectorsavailable (including FID and ECD)

Product literature

Pegasus BT

The Pegasus BT allows you to achieve all of the data you need from a single sample run, more data acquired, …


Pegasus BT 4D

The Pegasus BT 4D offers enhanced sensitivity by coupling our benchtop Pegasus BT with a high performance …


Pegasus GC-HRT+

Now with even more sensitivity than ever before, the Pegasus GC-HRT+ is the perfect tool for meeting the challenges …



The Pegasus GC-HRT+ 4D combines the highest performance GCxGC and TOFMS tools on the market …




That‘s what our users say:

Helmholtz Zentrum München (HMGU) Department “Comprehensive Molecular Analytics“, GERMANY

„This combination of ultrahigh chromatographic separation with high mass resolution might be still unique for a commercial
available end user system.“

Prof. Ralf Zimmermann

Food Chemistry Institute Cologne, Italy

“Pegasus BT is the perfect choice for identifying well-known metabolites at low concentration level in our sample, and also discovering new compounds. The most surprising advantage of the BT system is the ion source robustness! We usually work with dirty and complex samples, but we have never observed drop of sensitivity during our analyses.This reduces the time and cost of our analyses!”

Prof. Antonio Randazzon

Università degli Studi del Piemonte Orientale, Italy

„With the Pegasus BT 4D performing untargeted analysis today is very easy, thanks to the high sensitivity of the instrument, we are able to mine and analyze any type of sample! A combination of very good sensitivity, quality to price ratio and high flexibility make the Pegasus BT 4D system perfect for analysis of every sample”

Dott. Marcello Manfredi

Czech Academy of Science, Tschechische Republik

“Compared to GC equipped with a single column, the Pegasus 4D enabled me to separate unbelievable number of analytes! Tens of thousands of separated peaks in one run was not an exception. But where the separation was not perfect, ChromaTOF software and its deconvolution algorithm did the job. Such excellent ‘separating power’ helped me discover new types of plant PCB metabolites.“

Ing. Jan Rezek, Ph. D.

TURKU Metabolomics Facility, Finland

“We use the LECO Pegasus BT instrument for the quantification of small polar metabolites. We developed a hybrid method where we quantitate 51 metabolites with standard curves and screen for any other small polar metabolites in a wide range of biological samples. This assay has a great dynamic range thanks to the sensitivity of the BT. The StayClean® ion source allows us to run hundreds of samples in a batch and be confi dent that the ion source will remain clean even with dirty samples such as plasma.“

Alex Dickens

SGS Institut Fresenius GmbH Berlin, Germany

“We at SGS MOSH/MOAH group are using the GC × GC-TOFMS from LECO to separate the highly complex fractions of MOSH/MOAH contaminates in food. When you want to identify special patterns of contamination species amongst other analytics (e. g carotenoids) you need a high separation power in combination with a fast screening MS. This is provided by the LECO TOF. Actually we have a new project together with LECO and another company to quantify MOSH/MOAH fractions. The complexity of the instrumentation is high, but with the support of the application team from LECO we reach our goals.”

Silvia Aguiló Losa

ALS Enviromental, UK

“I believe this technology and methodology will profoundly change water analysis realising major benefi ts for both laboratories and their customers.“

John Quick, Principal Scientist

Unit 7, Rhino Court, Station View
Bramhall More Lane, Hazel Grove
Stockport SK7 5ER

Phone: +44 161 487 5900
Email: general_uk@leco.com

Contact us!
Get in Touch

Subscribe our Newsletter
Stay up to date